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KMID : 0928520090190020173
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Korean Journal of Lipidology
2009 Volume.19 No. 2 p.173 ~ p.182
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Association of Serum C-Reactive Protein Level with Severity of Angiographic Coronary Artery Disease in Stable Angina Patients
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Her Ae-young
Kim Yong-hoon
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Abstract
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Objective: The increased C-reactive protein (CRP) levels may portend the vulnerability of an atherosclerotic plaque and also contribute to plaque disruption. This study investigate the relationships between serum high-sensitivity CRP level and the extent and severity of coronary artery stenosis in stable angina patients by coronary angiography.
Methods: A total 200 patients undergoing percutaneous coronary angiography are enrolled. They are divided two groups; angiographic coronary artery stenosis group (Group A, n=100) and normal coronary angiogram group (Group B, n=100). The coronary angiograms are evaluated according to three scores: vessel score (0~4 points) stenosis score (1~4 points), and extent score (0~100 points)
Results: Serum CRP level was not significantly different between two groups (group A: 0.26±0.21 mg/dL, group B: 0.19±0.22 mg/dL, P=0.07). Serum CRP level and angiographic data (stenosis score, extent score) showed strong correlation (r=0.408, r=0.308, P<0.01) in group A.
Conclusion: In stable angina patients, serum hs-CRP could not showed significantly high level than normal coronary angiogram patients. But serum CRP and stenosis score and extent score showed significant correlation in group A.
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KEYWORD
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Atherosclerosis, Angiography, Stenosis, C-Reactive Protein
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